Two drivers were killed, and a third person was hospitalized in a wrong-way five-vehicle collision in Los Altos, Santa Clara County, on Thursday evening, October 22, 2026.
According to the California Highway Patrol, the crash occurred shortly after 5:00 p.m. on southbound Interstate 280 near Foothill Expressway.
CHP said a driver traveling in the northbound lanes crossed into the southbound lanes and struck four other vehicles.
Two drivers died in the collision. A third person was transported to a hospital, but their condition was not provided.
Investigators have not determined why the driver crossed into opposing traffic. The cause of the crash remains under investigation.
How Car Accident Lawyers Can Help
Car accidents involving several vehicles on a busy freeway can cause deadly and life-altering injuries. People who were hurt, as well as families who lost a loved one, may want guidance on their legal rights and the options available to them.
Car accident lawyers can help by reconstructing the sequence of impacts, reviewing the CHP investigation, and examining how each vehicle was involved. They may also assist in seeking compensation for medical care, funeral and burial costs, loss of companionship, and other damages where applicable.

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